Immuno-oncology

Harnessing the immune system to reimagine cancer care and help transform outcomes

Home / 澳门葡京赌博游戏的治疗领域 / 肿瘤学 / Immuno-oncology

利用免疫系统的力量

Our immune system has natural surveillance mechanisms to assess or eliminate potential threats to our health.^1,2 系统运行良好, but rogue cells sometimes slip past these surveillance mechanisms and become cancers.³ 通过为免疫系统提供识别肿瘤的工具, immuno-oncology therapies can enable recognition and response to the presence of cancer that our innate immune surveillance mechanisms may have missed.^1,4

跳转到部分:

大胆行动——解决未满足需求的领域
早期行动——致力于早期诊断和治疗
创新-探索下一代联合治疗策略
在聚光灯下

Immuno-oncology has been successful in the targeted treatment of cancer, but 最新进展 in our understanding of the immune system are informing the development of the next wave of therapies with the potential to make an even greater impact for patients across all stages of disease.

在澳门葡京网赌游戏, we’re pushing the boundaries of science with a relentless focus on harnessing the immune system to reimagine cancer care and help transform outcomes for patients.

大胆行动——解决未满足需求的领域

We have a history of boldly exploring novel immuno-oncology treatment approaches. We continually challenge the status quo with a focus on delivering novel treatment options to patients with high unmet need in areas where immuno-oncology may have the greatest impact, 包括许多生物学上特别困难的癌症. Our ambition is to bring novel immuno-oncology-based treatment approaches to new settings across gastrointestinal, 泌尿生殖器的, 肺癌和妇科癌症.

澳门葡京赌博游戏追求这一雄心壮志，不怕失败, gaining critical knowledge with each clinical trial that further advances our understanding of difficult-to-treat diseases with the potential to benefit a wider range of patients.

早期行动——致力于早期诊断和治疗

澳门葡京赌博游戏相信早期治疗癌症, where we can harness the immune system to recognise and eradicate cancer cells, has the greatest opportunity to maximise the potential for long-term remission and the possibility of cure.^5-7 而转移性疾病一直是癌症研究的重点领域, we realised the potential of treating cancer in earlier stages of disease and moving immuno-oncology treatment into the neoadjuvant (before surgery) and adjuvant (after surgery) settings.

Today, 澳门葡京赌博游戏是这个领域的领导者, with more than two-thirds of our Phase III trials in earlier stages of cancer. Our extensive early disease programmes provide potential for new and needed treatment options across a broad range of cancers.

澳门葡京赌博游戏希望越早发现和治疗癌症, 澳门葡京赌博游戏就越有可能帮助更多的病人活得更久. 这就是澳门葡京赌博游戏使用智能筛选工具的原因, exploring novel endpoints and establishing strategic partnerships to accelerate earlier immuno-oncology regimens that we believe will continue to play a critical role in revolutionising cancer care.

创新-探索下一代联合治疗策略

探索免疫肿瘤学的新领域

Innovation is central to our clinical strategy focused on exploring immuno-oncology in novel combinations to bring its promise to more patients and transform patient outcomes.

We have a diverse portfolio of immuno-oncology molecules and potential medicines and we’re continually investigating new mechanisms, 包括双特异性抗体, 新型检查点抑制剂, T细胞接合物, 细胞疗法, 来帮助驱动更持久的免疫反应. Our immuno-oncology assets are being assessed in combinations with a wide range of modalities, 无论是在澳门葡京赌博游戏的投资组合内部还是外部, including combinations with antibody drug conjugates that we believe may have the potential to replace conventional chemotherapy in immuno-oncology regimens.

除了, we’re studying innovative immuno-oncology combinations and unique dosing strategies to change the standard of care in advanced stage disease and help deliver clinically significant and sustained responses for patients.

We are balancing our focus on our pipeline with the active management of our existing medicines; expanding indications and exploring novel treatment combinations to deliver to those patients with the greatest unmet need. 澳门葡京赌博游戏的目标是推动多种肿瘤类型的长期生存, 疾病的阶段和治疗路线, 有可能改变癌症患者的生活方式.

在聚光灯下

肺癌

走在肺癌治疗的前沿

马克Cobbold

副总裁，发现，肿瘤R&D、澳门葡京网赌游戏

丹尼尔·弗里曼

澳门葡京网赌游戏早期发展肿瘤学副总裁

肝癌

确定肝癌的新靶点

澳门葡京赌博游戏的激情、澳门葡京赌博游戏的员工和创新文化推动着澳门葡京赌博游戏前进. 澳门葡京赌博游戏重视勇气, 好奇心, 具有协作精神和学习热情, and we encourage disruptive thinking where failure is an opportunity to learn – the freedom to take risks without fear of failure.

澳门葡京网赌游戏的职业

参考文献

1. Melero我, et al. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. 临床癌症研究中心. 2013;19(5):997-1008.

2. Finn O. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. 安杂志. 2012; 23 (Suppl_8): viii6-viii9.

3. 比蒂,GL. 免疫逃逸机制对癌症免疫治疗的指导作用. 临床癌症研究中心. 2015;21(4):687–692.

4. Eggermont, et al. 免疫肿瘤学进展. 安杂志. 2012; 23 (Suppl_8前言):viii5.

5. 英国癌症研究中心. 免疫系统和癌症. 可在:http://www.cancerresearchuk.org/about-cancer/what-is-cancer/body-systems-and-cancer/the-immune-system-and-cancer. 2022年10月发布.

6. 霍克斯N. 癌症生存数据强调早期诊断的重要性. BMJ. 2019;364:1408. 2022年10月发布.

7. 美国癌症协会. 为什么癌症患者更容易感染. 可在:http://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/low-blood-counts/infections/why-people-with-cancer-are-at-risk.html. 2022年10月发布.